Basic Info
Model NO.: CAS 69-65-8
Customized: Customized
Suitable for: Adult
Purity: >99%
Alias: Sodiumcroscarmellose
Grade: Pharmaceutical Grade
Trademark: OrientalTX
Specification: Pharmaceutical Grade
HS Code: 2937390000
Powder: Yes
Certification: GMP, ISO 9001, USP, BP
State: Solid
Product Name: Croscarmellose Sodium
CAS: 74811-65-7
Appearance: White Crystalline Powder
Transport Package: Disguised Packing for Delivery Guarantee!
Origin: China
Product Description
Pharmaceutical Chemical Raw Material Mannitol
Croscarmellose sodium is an internally cross-linked sodium carboxymethylcellulose for use as a super-disintegrant in pharmaceutical formulations.
The cross-linking reduces water solubility while still allowing the material to swell (like a sponge) and absorb many times its weight in water. As a result, it provides superior drug dissolution and disintegration characteristics, thus improving formulas′ subsequent bioavailability by bringing the active ingredients into better contact with bodily fluids.
Croscarmellose sodium also resolves formulators′ concerns over long-term functional stability, reduced effectiveness at high tablet hardness levels, and similar problems associated with other products developed to enhance drug dissolution. Croscarmellose sodium is a very commonly used pharmaceutical additive.Its purpose in most tablets - including dietary supplements - is to assist the tablet in disintegrating in the gastrointestinal tract promptly. If a tablet disintegrating agent is not included, the tablet could disintegrate too slowly, in the wrong part of the intestine or not at all, thereby reducing the efficacy and bioavailability of the active ingredients.
Croscarmellose is made by first soaking crude cellulose in sodium hydroxide, and then reacting the cellulose with sodium monochloroacetate to form sodium carboxymethylcellulose. Excess sodium monochloroacetate slowly hydrolyzes to glycolic acid and the glycolic acid catalyzes the cross-linkage to form croscarmellose sodium.Chemically, croscarmellose sodium is the sodium salt of a cross-linked, partly O-(carboxymethylated) cellulose.
| Product Name | Croscarmellose Sodium |
| Alias | Sodiumcroscarmellose |
| CAS | 74811-65-7 |
| Assay | 99% |
| Grade | Pharmaceutical Grade |
| Appearance | White Crystalline Powder |
Croscarmellose sodium is an internally cross-linked sodium carboxymethylcellulose for use as a super-disintegrant in pharmaceutical formulations.
The cross-linking reduces water solubility while still allowing the material to swell (like a sponge) and absorb many times its weight in water. As a result, it provides superior drug dissolution and disintegration characteristics, thus improving formulas′ subsequent bioavailability by bringing the active ingredients into better contact with bodily fluids.
Croscarmellose sodium also resolves formulators′ concerns over long-term functional stability, reduced effectiveness at high tablet hardness levels, and similar problems associated with other products developed to enhance drug dissolution. Croscarmellose sodium is a very commonly used pharmaceutical additive.Its purpose in most tablets - including dietary supplements - is to assist the tablet in disintegrating in the gastrointestinal tract promptly. If a tablet disintegrating agent is not included, the tablet could disintegrate too slowly, in the wrong part of the intestine or not at all, thereby reducing the efficacy and bioavailability of the active ingredients.
Croscarmellose is made by first soaking crude cellulose in sodium hydroxide, and then reacting the cellulose with sodium monochloroacetate to form sodium carboxymethylcellulose. Excess sodium monochloroacetate slowly hydrolyzes to glycolic acid and the glycolic acid catalyzes the cross-linkage to form croscarmellose sodium.Chemically, croscarmellose sodium is the sodium salt of a cross-linked, partly O-(carboxymethylated) cellulose.